A set of chemically derived medicines that successfully supresses the inflammation-creating responses of tumour necrosis factor or TNF, TNF antagonist drugs play a key role in IBD cure by helping patients combat an array of symptoms and clinical reposes related to various autoimmune disorders like Crohn’s disease and ulcerative colitis. Though these medicines help supress inflammatory bowel disease conditions, extensive usage of these drugs can do more harm than good, as they might leave significant side effects that can be as serious and life threatening as lymphoma, heart failure, and lupus-like diseases. Yet, these medicines have been widely recommended by physicians around the world, as they are strong enough to disarm IBD symptoms and keep them under control, before they wreck terrible havoc that might cause chronic inflammation, as well as several other symptoms, including acute diarrhoea, stomach pain, cramps, nausea, vomiting, weight loss and terrible fatigue that no one can easily bear with.
That said, knowing what TNF is will help know the impacts of TNF on the gastrointestinal tract. TNF or tumour necrosis factor can be defined as a bioactive pro-inflammatory cytokine that regulates inflammatory responses of immune cells. Cytokines are chemical substances like interferon and interleukin, which are secreted by a few cells of the immune system, and help deliver messages between cells in the body. TNF antagonist drugs for IBD target the effects of TNF, and thereby supress the unnatural inflammatory actions. The commonly used TNF blocker drugs are:
Enbrel
Remicade
Humira
Simponi
Cimzia
Some quick facts on TNF and anti-TNF drugs:
Ant-TNF drugs target the unnatural actions of inflammation causing Tumour necrosis factor alpha
TNF antagonists are used for the treatment of disease like IBD and rheumatoid arthritis
The can control inflammation in digestive tracks, joints, and skin.
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